The entire direction of the Marvel Cinematic Universe has been entirely uprooted. After Avengers: Endgame, the overarching narrative pivoted from a grounded battle against Thanos to a multiverse-spanning arc. This has been slowly pitting the heroes against various variants of Jonathan Majors' Kang the Conqueror. After Majors was found guilty of assault and harassment, however, Marvel Studios officially fired Majors.
10 Villains Who Can Replace Kang In The MCU
If Marvel Studios decides to move on from Kang the Conqueror's role as the existential threat of the MCU, there are villains who can take his place.